Anti-TMC8 antibody (601-650 aa) (STJ96041)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TMC8 at the amino acid range 601-650
General Information
| Short Description | Rabbit polyclonal anti-Transmembrane channel-like protein 8 (601-650 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TMC8 |
| Gene ID | 147138 |
| Uniprot ID | TMC8_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TMC8 at the amino acid range 601-650 |
| Immunogen Region | 601-650 aa |
| Specificity | TMC8 Polyclonal Antibody detects endogenous levels of TMC8 protein. |
Additional Info
| Function | Acts as a regulatory protein involved in the regulation of numerous cellular processes. Together with its homolog TMC6/EVER1, forms a complex with calcium-binding protein CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 levels and reciprocally. Together with TMC6, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER. Also inhibits receptor-mediated calcium release from ER stores and calcium activated and volume regulated chloride channels. Down-regulates the activity of transcription factors induced by zinc and cytokines. Also sequesters TRADD which impairs the recruitment of TRAF2 and RIPK1 in the pro-survival complex I and promotes proapoptotic complex II formation, and may therefore be involved in TNF-induced cell death/survival decisions. |
| Protein Name | Transmembrane Channel-Like Protein 8Epidermodysplasia Verruciformis Protein 2 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneNucleus MembraneLocalizes To The ErGolgi And Nucleus Membranes In Keratinocytes |
| Alternative Antibody Names | Anti-Transmembrane Channel-Like Protein 8 antibodyAnti-Epidermodysplasia Verruciformis Protein 2 antibodyAnti-TMC8 antibodyAnti-EVER2 antibodyAnti-EVIN2 antibody |
Information sourced from Uniprot.org