| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TMC6 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
TMC6 |
| Gene ID: |
11322 |
| Uniprot ID: |
TMC6_HUMAN |
| Specificity: |
Specific for TMC6. |
| Immunogen: |
A synthetic peptide from the 2d cytoplasmic loop of human transmembrane channel-like protein 6 (TMC6, EVER1, Protein LAK-4, EVIN1) conjugated to an immunogenic carrier protein was used as the antigen. |
| Function | Acts as a regulatory protein involved in the regulation of numerous cellular processes. Together with its homolog TMC8/EVER2, forms a complex with CIB1 in lymphocytes and keratynocytes where TMC6 and TMC8 stabilize CIB1 and reciprocally. Together with TMC8, also forms a complex with and activates zinc transporter ZNT1 at the ER membrane of keratynocytes, thereby facilitating zinc uptake into the ER. Down-regulates the activity of transcription factors induced by zinc and cytokines. Also plays a role in thermal sensation by inhibiting the M-channel (KCNQ2-KCNQ3 channel) current in primary sensory neurons. |
| Protein Name | Transmembrane Channel-Like Protein 6Epidermodysplasia Verruciformis Protein 1Protein Lak-4 |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneNucleus MembraneLocalizes To The ErGolgi And Nucleus Membranes In Keratinocytes |
| Alternative Antibody Names | Anti-Transmembrane Channel-Like Protein 6 antibodyAnti-Epidermodysplasia Verruciformis Protein 1 antibodyAnti-Protein Lak-4 antibodyAnti-TMC6 antibodyAnti-EVER1 antibodyAnti-EVIN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
