| Post Translational Modifications | Ubiquitinated by BFAR, leading to proteasomal degradation. |
| Function | Endoplasmic reticulum (ER)-resident protein that confers cellular protection as an anti-apoptotic protein by limiting multiple stress-inducing pathways surrounding the endoplasmic reticulum and mitochondria. Inhibits the activities of the key sensor for the endoplasmic reticulum unfolded protein response IRE1alpha/ERN1 both directly and by blocking BAX/BAK binding. Modulates ER calcium homeostasis by acting as a calcium-leak channel. Negatively regulates autophagy and autophagosome formation, especially during periods of nutrient deprivation, and reduces cell survival during starvation. |
| Protein Name | Bax Inhibitor 1Bi-1Testis-Enhanced Gene Transcript ProteinTransmembrane Bax Inhibitor Motif-Containing Protein 6 |
| Database Links | |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Bax Inhibitor 1 antibodyAnti-Bi-1 antibodyAnti-Testis-Enhanced Gene Transcript Protein antibodyAnti-Transmembrane Bax Inhibitor Motif-Containing Protein 6 antibodyAnti-TMBIM6 antibodyAnti-BI1 antibodyAnti-TEGT antibody |
Information sourced from Uniprot.org
