Anti-TLR8/CD288 antibody [303F1.14] {Alexa-fluor-647} (STJ16102357)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAlexa-fluor-647
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal anti-TLR8/CD288 for use in FACS in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FACS |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 303F1.14 |
| Isotype | IgG2a |
| Conjugation | Alexa-fluor-647 |
| Concentration | 0.5 mg/mL |
| Purification | Affinity Purified |
| Formulation | TRIS, PBS, pH7 and antibiotics |
| Storage Instruction | Store at-20ยฐC for up to 1 year. |
Target Information
| Gene Symbol | Tlr8 |
| Gene ID | 170744 |
| Uniprot ID | TLR8_MOUSE |
Additional Info
| Function | Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. |
| Protein Name | Toll-Like Receptor 8Cd Antigen Cd288 |
| Database Links | Reactome: R-MMU-1679131 |
| Cellular Localisation | Endosome MembraneSingle-Pass Type I Membrane ProteinEndosomal Localization Confers Distinctive Proteolytic Processing |
| Alternative Antibody Names | Anti-Toll-Like Receptor 8 antibodyAnti-Cd Antigen Cd288 antibodyAnti-Tlr8 antibody |
Information sourced from Uniprot.org