| Host: | Mouse |
| Applications: | FACS |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-TLR8/CD288 is suitable for use in FACS research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 303F1.14 |
| Conjugation: | Alexa-fluor-647 |
| Isotype: | IgG2a |
| Formulation: | TRIS, PBS, pH7 and antibiotics |
| Purification: | Affinity Purified |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for up to 1 year. |
| Gene Symbol: | Tlr8 |
| Gene ID: | 170744 |
| Uniprot ID: | TLR8_MOUSE |
| Function | Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. |
| Protein Name | Toll-Like Receptor 8 Cd Antigen Cd288 |
| Database Links | Reactome: R-MMU-1679131 |
| Cellular Localisation | Endosome Membrane Single-Pass Type I Membrane Protein Endosomal Localization Confers Distinctive Proteolytic Processing |
| Alternative Antibody Names | Anti-Toll-Like Receptor 8 antibody Anti-Cd Antigen Cd288 antibody Anti-Tlr8 antibody |
Information sourced from Uniprot.org