| Host: |
Mouse |
| Applications: |
ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Short Description : |
Mouse monoclonal antibody anti-Toll-Like Receptor 7 is suitable for use in ELISA research applications. |
| Clonality : |
Monoclonal |
| Clone ID : |
SAA1718 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG2a |
| Formulation: |
0.01M PBS |
| Purification: |
Protein A/G purified from cell culture supernatant |
| Concentration: |
1 mg/mL |
| Storage Instruction: |
Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
| Function | Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of uridine-containing single strand RNAs (ssRNAs) of viral origin or guanosine analogs. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-containing downstream adapter MYD88 through homotypic interaction. In turn, the Myddosome signaling complex is formed involving IRAK4, IRAK1, TRAF6, TRAF3 leading to activation of downstream transcription factors NF-kappa-B and IRF7 to induce pro-inflammatory cytokines and interferons, respectively. |
| Protein Name | Toll-Like Receptor 7 |
| Database Links | Reactome: R-HSA-1679131Reactome: R-HSA-168181Reactome: R-HSA-5686938Reactome: R-HSA-9679191Reactome: R-HSA-9692916Reactome: R-HSA-9705671Reactome: R-HSA-975110Reactome: R-HSA-975138Reactome: R-HSA-975155Reactome: R-HSA-9824856Reactome: R-HSA-9833110 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Type I Membrane ProteinEndosomeLysosomeCytoplasmic VesiclePhagosomeRelocalizes From Endoplasmic Reticulum To Endosome And Lysosome Upon Stimulation With Agonist |
| Alternative Antibody Names | Anti-Toll-Like Receptor 7 antibodyAnti-TLR7 antibodyAnti-UNQ248 antibodyAnti-PRO285 antibody |
Information sourced from Uniprot.org
