| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Toll-like receptor 5 (730-810 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TLR5 |
| Gene ID: | 7100 |
| Uniprot ID: | TLR5_HUMAN |
| Immunogen Region: | 730-810 aa |
| Specificity: | TLR5 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 730-810 |
| Post Translational Modifications | Phosphorylated at Ser-805 by PKD/PRKD1.phosphorylation induces the production of inflammatory cytokines. Phosphorylated at Tyr-798 upon flagellin binding.required for signaling. |
| Function | Pattern recognition receptor (PRR) located on the cell surface that participates in the activation of innate immunity and inflammatory response. Recognizes small molecular motifs named pathogen-associated molecular pattern (PAMPs) expressed by pathogens and microbe-associated molecular patterns (MAMPs) usually expressed by resident microbiota. Upon ligand binding such as bacterial flagellins, recruits intracellular adapter proteins MYD88 and TRIF leading to NF-kappa-B activation, cytokine secretion and induction of the inflammatory response. Plays thereby an important role in the relationship between the intestinal epithelium and enteric microbes and contributes to the gut microbiota composition throughout life. |
| Protein Name | Toll-Like Receptor 5 Toll/Interleukin-1 Receptor-Like Protein 3 |
| Database Links | Reactome: R-HSA-168176 Reactome: R-HSA-5602680 Reactome: R-HSA-5603037 Reactome: R-HSA-975871 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Toll-Like Receptor 5 antibody Anti-Toll/Interleukin-1 Receptor-Like Protein 3 antibody Anti-TLR5 antibody Anti-TIL3 antibody |
Information sourced from Uniprot.org