Anti-TLK2 antibody (191-240 aa) (STJ96039)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TLK2 at the amino acid range 191-240
General Information
| Short Description | Rabbit polyclonal anti-Serine/threonine-protein kinase tousled-like 2 (191-240 aa) for use in WB, ELISA and IHC in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TLK2 |
| Gene ID | 11011 |
| Uniprot ID | TLK2_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TLK2 at the amino acid range 191-240 |
| Immunogen Region | 191-240 aa |
| Specificity | TLK2 Polyclonal Antibody detects endogenous levels of TLK2 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated at Ser-750, probably by CHEK1. Autophosphorylated.phosphorylation promotes the assembly of higher order oligomers and enzymatic activity. |
| Function | Serine/threonine-protein kinase involved in the process of chromatin assembly and probably also DNA replication, transcription, repair, and chromosome segregation. Phosphorylates the chromatin assembly factors ASF1A and ASF1B. Phosphorylation of ASF1A prevents its proteasome-mediated degradation, thereby enhancing chromatin assembly. Negative regulator of amino acid starvation-induced autophagy. |
| Protein Name | Serine/Threonine-Protein Kinase Tousled-Like 2HshpkPku-AlphaTousled-Like Kinase 2 |
| Database Links | |
| Cellular Localisation | NucleusNucleoplasmCytoplasmPerinuclear RegionCytoskeletonColocalizes With The Cytoplasmic Intermediate Filament System During The G1 Phase Of The Cell CyclePresent In The Perinuclear Region At S Phase And In The Nucleus At Late G2 |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tousled-Like 2 antibodyAnti-Hshpk antibodyAnti-Pku-Alpha antibodyAnti-Tousled-Like Kinase 2 antibodyAnti-TLK2 antibody |
Information sourced from Uniprot.org