| Host: | Rabbit |
| Applications: | WB/IHC-P/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 IHC-P:1:50-1:100 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TLK1 |
| Gene ID: | 9874 |
| Uniprot ID: | TLK1_HUMAN |
| Immunogen Region: | 160-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 160-230 of human TLK1 (NP_036422.3). |
| Immunogen Sequence: | PVRGIPPAIRSPQNSHSHST PSSSVRPNSPSPTALAFGDH PIVQPKQLSFKIIQTDLTML KLAALESNKIQ |
| Tissue Specificity | Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. |
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
| Protein Name | Serine/Threonine-Protein Kinase Tousled-Like 1 Pku-Beta Tousled-Like Kinase 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tousled-Like 1 antibody Anti-Pku-Beta antibody Anti-Tousled-Like Kinase 1 antibody Anti-TLK1 antibody Anti-KIAA0137 antibody |
Information sourced from Uniprot.org