| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Serine/Threonine-Protein Kinase Tousled-Like 1 (150-250) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TLK1 |
| Gene ID: |
9874 |
| Uniprot ID: |
TLK1_HUMAN |
| Immunogen Region: |
150-250 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 150-250 of human TLK1 (NP_036422.3). |
| Immunogen Sequence: |
FEYQGGNGSSPVRGIPPAIR SPQNSHSHSTPSSSVRPNSP SPTALAFGDHPIVQPKQLSF KIIQTDLTMLKLAALESNKI QDLEKKEGRIDDLLRANCDL R |
| Tissue Specificity | Widely expressed. Present in fetal placenta, liver, kidney and pancreas but not heart or skeletal muscle. Also found in adult cell lines. Isoform 3 is ubiquitously expressed in all tissues examined. |
| Function | Rapidly and transiently inhibited by phosphorylation following the generation of DNA double-stranded breaks during S-phase. This is cell cycle checkpoint and ATM-pathway dependent and appears to regulate processes involved in chromatin assembly. Isoform 3 phosphorylates and enhances the stability of the t-SNARE SNAP23, augmenting its assembly with syntaxin. Isoform 3 protects the cells from the ionizing radiation by facilitating the repair of DSBs. In vitro, phosphorylates histone H3 at 'Ser-10'. |
| Protein Name | Serine/Threonine-Protein Kinase Tousled-Like 1Pku-BetaTousled-Like Kinase 1 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Serine/Threonine-Protein Kinase Tousled-Like 1 antibodyAnti-Pku-Beta antibodyAnti-Tousled-Like Kinase 1 antibodyAnti-TLK1 antibodyAnti-KIAA0137 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
