| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Transducin-like enhancer protein 1 homolog (300-350 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TLE1 |
| Gene ID: | 7088 |
| Uniprot ID: | TLE1_HUMAN |
| Immunogen Region: | 300-350 aa |
| Specificity: | This antibody detects endogenous levels of TLE1 at Human/Mouse |
| Immunogen: | Synthesized peptide derived from the human TLE1 at the amino acid range 300-350 |
| Post Translational Modifications | Phosphorylated, probably by CDK1. The degree of phosphorylation varies throughout the cell cycle, and is highest at the G2/M transition. Becomes hyperphosphorylated in response to cell differentiation and interaction with HES1 or RUNX1. Ubiquitinated by XIAP/BIRC4. |
| Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits NF-kappa-B-regulated gene expression. Inhibits the transcriptional activation mediated by FOXA2, and by CTNNB1 and TCF family members in Wnt signaling. Enhances FOXG1/BF-1- and HES1-mediated transcriptional repression. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Unusual function as coactivator for ESRRG. |
| Protein Name | Transducin-Like Enhancer Protein 1 E(Sp1 Homolog Enhancer Of Split Groucho-Like Protein 1 Esg1 |
| Database Links | Reactome: R-HSA-201722 Reactome: R-HSA-2122947 Reactome: R-HSA-3769402 Reactome: R-HSA-4641265 |
| Cellular Localisation | Nucleus Nuclear And Chromatin-Associated Depending On Isoforms And Phosphorylation Status Hyperphosphorylation Decreases The Affinity For Nuclear Components |
| Alternative Antibody Names | Anti-Transducin-Like Enhancer Protein 1 antibody Anti-E(Sp1 Homolog antibody Anti-Enhancer Of Split Groucho-Like Protein 1 antibody Anti-Esg1 antibody Anti-TLE1 antibody |
Information sourced from Uniprot.org