Anti-TIRAP antibody (52-101 aa) (STJ96032)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human TIRAP at the amino acid range 52-101
General Information
| Short Description | Rabbit polyclonal anti-Toll/interleukin-1 receptor domain-containing adapter protein (52-101 aa) for use in IHC, IF, WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF/WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC 1:100-1:300ELISA 1:20000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TIRAP |
| Gene ID | 114609 |
| Uniprot ID | TIRAP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human TIRAP at the amino acid range 52-101 |
| Immunogen Region | 52-101 aa |
| Specificity | TIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein. |
Additional Info
| Post Translational Modifications | Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation. |
| Function | Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6). |
| Protein Name | Toll/Interleukin-1 Receptor Domain-Containing Adapter ProteinTir Domain-Containing Adapter ProteinAdaptor Protein WyattMyd88 Adapter-Like ProteinMyd88-2 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-166058Reactome: R-HSA-5602498Reactome: R-HSA-5603041 |
| Cellular Localisation | CytoplasmCell MembraneMembraneColocalizes With Dab2ip At The Plasma Membrane |
| Alternative Antibody Names | Anti-Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein antibodyAnti-Tir Domain-Containing Adapter Protein antibodyAnti-Adaptor Protein Wyatt antibodyAnti-Myd88 Adapter-Like Protein antibodyAnti-Myd88-2 antibodyAnti-TIRAP antibodyAnti-MAL antibody |
Information sourced from Uniprot.org