• Immunohistochemical analysis of paraffin-embedded Human brain. Antibody was diluted at 1:100 (4°C overnight). High-pressure and temperature Tris-EDTA, pH8.0 was used for antigen retrieval. Negetive contrl (right) obtaned from antibody was pre-absorbed by immunogen peptide.

Anti-TIRAP antibody (52-101 aa) (STJ96032)

SKU:
STJ96032

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF/WB/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Toll/interleukin-1 receptor domain-containing adapter protein (52-101 aa) is suitable for use in Immunohistochemistry, Immunofluorescence, Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
IHC 1:100-1:300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TIRAP
Gene ID: 114609
Uniprot ID: TIRAP_HUMAN
Immunogen Region: 52-101 aa
Specificity: TIRAP Polyclonal Antibody detects endogenous levels of TIRAP protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human TIRAP at the amino acid range 52-101
Post Translational Modifications Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation.
Function Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6).
Protein Name Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein
Tir Domain-Containing Adapter Protein
Adaptor Protein Wyatt
Myd88 Adapter-Like Protein
Myd88-2
Database Links Reactome: R-HSA-1236974
Reactome: R-HSA-166058
Reactome: R-HSA-5602498
Reactome: R-HSA-5603041
Cellular Localisation Cytoplasm
Cell Membrane
Membrane
Colocalizes With Dab2ip At The Plasma Membrane
Alternative Antibody Names Anti-Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein antibody
Anti-Tir Domain-Containing Adapter Protein antibody
Anti-Adaptor Protein Wyatt antibody
Anti-Myd88 Adapter-Like Protein antibody
Anti-Myd88-2 antibody
Anti-TIRAP antibody
Anti-MAL antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance