| Tissue Specificity | Highly expressed in liver, kidney, spleen, skeletal muscle and heart. Also detected in peripheral blood leukocytes, lung, placenta, small intestine, thymus, colon and brain. |
| Post Translational Modifications | Phosphorylated by IRAK1 and IRAK4. Also phosphorylated by BTK. Polyubiquitinated. Polyubiquitination follows phosphorylation by BTK and leads to TIRAP degradation. |
| Function | Adapter involved in TLR2, TLR4 and RAGE signaling pathways in the innate immune response. Acts via IRAK2 and TRAF-6, leading to the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting in cytokine secretion and the inflammatory response. Positively regulates the production of TNF-alpha (TNF) and interleukin-6 (IL6). |
| Protein Name | Toll/Interleukin-1 Receptor Domain-Containing Adapter ProteinTir Domain-Containing Adapter ProteinAdaptor Protein WyattMyd88 Adapter-Like ProteinMyd88-2 |
| Database Links | Reactome: R-HSA-1236974Reactome: R-HSA-166058Reactome: R-HSA-5602498Reactome: R-HSA-5603041 |
| Cellular Localisation | CytoplasmCell MembraneMembraneColocalizes With Dab2ip At The Plasma Membrane |
| Alternative Antibody Names | Anti-Toll/Interleukin-1 Receptor Domain-Containing Adapter Protein antibodyAnti-Tir Domain-Containing Adapter Protein antibodyAnti-Adaptor Protein Wyatt antibodyAnti-Myd88 Adapter-Like Protein antibodyAnti-Myd88-2 antibodyAnti-TIRAP antibodyAnti-MAL antibody |
Information sourced from Uniprot.org
