Anti-TIPRL antibody [3D11] (STJA0032639)

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STJA0032639
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Host: Mouse
Applications: WB/FC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-TIPRL for use in WB and FC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : 3D11
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3.
Purification: Affinity Purified
Concentration: 0.79 mg/mL
Dilution Range: WB 1:500-1:1000
FC 1:50-1:100
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: TIPRL
Gene ID: 261726
Uniprot ID: TIPRL_HUMAN
Immunogen: Full length human recombinant protein of human TIPRL produced in 293T cell.
Function May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex.the function is proposed to implicate it in DNA damage response by promoting H2AX phosphorylated on Ser-140 (gamma-H2AX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.
Protein Name Tip41-Like Protein
Putative Mapk-Activating Protein Pm10
Type 2a-Interacting Protein
Tip
Database Links
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Tip41-Like Protein antibody
Anti-Putative Mapk-Activating Protein Pm10 antibody
Anti-Type 2a-Interacting Protein antibody
Anti-Tip antibody
Anti-TIPRL antibody

Information sourced from Uniprot.org

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