| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TIMP3 (24-211) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TIMP3 |
| Gene ID: |
7078 |
| Uniprot ID: |
TIMP3_HUMAN |
| Immunogen Region: |
24-211 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1). |
| Immunogen Sequence: |
CTCSPSHPQDAFCNSDIVIR AKVVGKKLVKEGPFGTLVYT IKQMKMYRGFTKMPHVQYIH TEASESLCGLKLEVNKYQYL LTGRVYDGKMYTGLCNFVER WDQLTLSQRKGLNYRYHLGC NCKIKSCYYLPCFVTSKNEC LWTDMLSNFGYPGYQSKHYA CIRQKGGYCSWYRGWAPPDK SIINATDP |
| Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. |
| Protein Name | Metalloproteinase Inhibitor 3Protein Mig-5Tissue Inhibitor Of Metalloproteinases 3Timp-3 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 3 antibodyAnti-Protein Mig-5 antibodyAnti-Tissue Inhibitor Of Metalloproteinases 3 antibodyAnti-Timp-3 antibodyAnti-TIMP3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
