| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:100-1:500IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TIMP3 |
| Gene ID: | 7078 |
| Uniprot ID: | TIMP3_HUMAN |
| Immunogen Region: | 24-211 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 24-211 of human TIMP3 (NP_000353.1). |
| Immunogen Sequence: | CTCSPSHPQDAFCNSDIVIR AKVVGKKLVKEGPFGTLVYT IKQMKMYRGFTKMPHVQYIH TEASESLCGLKLEVNKYQYL LTGRVYDGKMYTGLCNFVER WDQLTLSQRKGLNYRYHLGC NCKIKSCYYLPCFVTSKNEC LWTDMLSNFGYPGYQSKHYA CIRQKGGYCSWYRGWAPPDK SIINATDP |
| Function | Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13, MMP-14 and MMP-15. |
| Protein Name | Metalloproteinase Inhibitor 3Protein Mig-5Tissue Inhibitor Of Metalloproteinases 3Timp-3 |
| Database Links | Reactome: R-HSA-114608 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Metalloproteinase Inhibitor 3 antibodyAnti-Protein Mig-5 antibodyAnti-Tissue Inhibitor Of Metalloproteinases 3 antibodyAnti-Timp-3 antibodyAnti-TIMP3 antibody |
Information sourced from Uniprot.org