Anti-TIMP2 antibody (100-200) [S4844RM] (STJ11104844)

Name: Anti-TIMP2 antibody (100-200) [S4844RM] (STJ11104844)
SKU: STJ11104844
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityMonoclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11104844

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Short Description	Rabbit monoclonal Metalloproteinase Inhibitor 2 (100-200) antibody for use in WB and ELISA in human, mouse, rat and african green monkey samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat/African green monkey
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Monoclonal
Clone ID	S4844RM
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	TIMP2
Gene ID	7077
Uniprot ID	TIMP2_HUMAN
Immunogen Region	100-200
Immunogen Sequence	VSLDVGGKKEYLIAGKAEGD GKMHITLCDFIVPWDTLSTT QKKSLNHRYQMGCECKITRC PMIPCYISSPDECLWMDWVT EKNINGHQAKFFACIKRSDG S
Specificity	A synthetic peptide corresponding to a sequence within amino acids 100-200 of human TIMP2 (NP_003246.1).

Post Translational Modifications	The activity of TIMP2 is dependent on the presence of disulfide bonds.
Function	Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. Known to act on MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-13, MMP-14, MMP-15, MMP-16 and MMP-19.
Protein Name	Metalloproteinase Inhibitor 2 Csc-21k Tissue Inhibitor Of Metalloproteinases 2 Timp-2
Database Links	Reactome: R-HSA-1592389 Reactome: R-HSA-6798695 Reactome: R-HSA-9839383
Cellular Localisation	Secreted
Alternative Antibody Names	Anti-Metalloproteinase Inhibitor 2 antibody Anti-Csc-21k antibody Anti-Tissue Inhibitor Of Metalloproteinases 2 antibody Anti-Timp-2 antibody Anti-TIMP2 antibody

Information sourced from Uniprot.org