Anti-TIAR antibody [6E3] (STJ16103403)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2ak
ImmunogenGST-tagged recombinant human TIAR
General Information
| Short Description | Mouse monoclonal anti-TIAR for use in WB, IHC-P, ICC, FC and ELISA in Human, Mouse and Non-Human Primates samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/FC/ELISA |
| Host | Mouse |
| Reactivity | Human/Mouse/Non-Human Primates |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 6E3 |
| Isotype | IgG2ak |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by protein-A affinity chromatography. |
| Formulation | Phosphate buffered saline (PBS) , pH 7.4, 15 mM sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Gene Symbol | TIAL1 |
| Gene ID | 7073 |
| Uniprot ID | TIAR_HUMAN |
| Immunogen | GST-tagged recombinant human TIAR |
Additional Info
| Post Translational Modifications | Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA. |
| Function | RNA-binding protein involved in alternative pre-RNA splicing and in cytoplasmic stress granules formation. Shows a preference for uridine-rich RNAs. Activates splicing of alternative exons with weak 5' splice sites followed by a U-rich stretch on its own pre-mRNA and on TIA1 mRNA. Promotes the inclusion of TIA1 exon 5 to give rise to the long isoform (isoform a) of TIA1. Acts downstream of the stress-induced phosphorylation of EIF2S1/EIF2A to promote the recruitment of untranslated mRNAs to cytoplasmic stress granules (SG). Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. |
| Protein Name | Nucleolysin TiarTia-1-Related Protein |
| Database Links | Reactome: R-HSA-6803529 |
| Cellular Localisation | NucleusCytoplasmCytolytic GranuleStress GranuleNuclear Import Seems To Be Coupled To Rna Polymerase Ii Transcription And May Be Dependent On Rna-BindingAccumulates In Cytoplasmic Stress Granules (Sg) Following Cellular Damage |
| Alternative Antibody Names | Anti-Nucleolysin Tiar antibodyAnti-Tia-1-Related Protein antibodyAnti-TIAL1 antibody |
Information sourced from Uniprot.org