![Anti-Thyroid Transcription Factor-1 antibody [SPT24] (STJ16101797)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/152303/347150/STJ16101797_1__33525.1681999423.jpg?c=1 "Anti-Thyroid Transcription Factor-1 antibody [SPT24] (STJ16101797)")
![Anti-Thyroid Transcription Factor-1 antibody [SPT24] (STJ16101797)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/152303/347150/STJ16101797_1__33525.1681999423.jpg?c=1 "Anti-Thyroid Transcription Factor-1 antibody [SPT24] (STJ16101797)")
Anti-Thyroid Transcription Factor-1 antibody [SPT24] (STJ16101797)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1
ImmunogenProkaryotic recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of the TTF-1 molecule.
General Information
| Short Description | Mouse monoclonal anti-Thyroid Transcription Factor-1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC-P |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SPT24 |
| Isotype | IgG1 |
| Conjugation | Unconjugated |
| Concentration | >=108 mg/L |
| Dilution Range | IHC-P 1:200 |
| Formulation | Tissue culture supernatant with sodium azide |
| Storage Instruction | Store at 2-8°C for up to 1-year, upon receipt. |
Target Information
| Immunogen | Prokaryotic recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of the TTF-1 molecule. |
Additional Info
| Background | Thyroid Transcription Factor-1 (TTF-1) is a member of the homeodomain transcription factor family and plays a role in regulating genes expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins. Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sharing 98% homology with the equivalent rat and mouse proteins. TTF-1 functions by binding to specific recognition sites in a manner that may be regulated by both the redox and phosphorylation status of the protein. In addition to its role as a tissue-specific transcriptional activator in adult organs, TTF-1 may also function in organogenesis. Gene targeting studies have shown TTF-1 to be essential for the proper development of the thyroid and lungs and abnormal expression may underline a number of congenital abnormalities. |
Information sourced from Uniprot.org