Anti-Thyroid Transcription Factor-1 antibody [SPT24] (STJ16101797)

Anti-Thyroid Transcription Factor-1 antibody [SPT24] (STJ16101797)

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STJ16101797-1
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Host: Mouse
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal antibody anti-Thyroid Transcription Factor-1 is suitable for use in Immunohistochemistry research applications.
Clonality : Monoclonal
Clone ID : SPT24
Conjugation: Unconjugated
Isotype: IgG1
Formulation: Tissue culture supernatant with sodium azide
Concentration: >=108 mg/L
Dilution Range: IHC-P 1:200
Storage Instruction: Store at 2-8°C upon receipt.
Immunogen: Prokaryotic recombinant protein corresponding to a 123 amino acid fragment of the N-terminal region of the TTF-1 molecule.
Background Thyroid Transcription Factor-1 (TTF-1) is a member of the homeodomain transcription factor family and plays a role in regulating genes expressed within the thyroid, lung and brain. These include thyroglobulin, thyroid peroxidase, Clara cell secretory protein and surfactant proteins. Human TTF-1 (38 kD) is a single polypeptide of 371 amino acids sharing 98% homology with the equivalent rat and mouse proteins. TTF-1 functions by binding to specific recognition sites in a manner that may be regulated by both the redox and phosphorylation status of the protein. In addition to its role as a tissue-specific transcriptional activator in adult organs, TTF-1 may also function in organogenesis. Gene targeting studies have shown TTF-1 to be essential for the proper development of the thyroid and lungs and abnormal expression may underline a number of congenital abnormalities.

Information sourced from Uniprot.org

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