Anti-Thyroid Transcription Factor 1 antibody [BP6079] (STJA0037633)

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STJA0037633
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Host: Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit monoclonal anti-Thyroid Transcription Factor 1 for use in IHC-P in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : BP6079
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
Purification: Affinity Purified
Dilution Range: IHC 1:100-1:200
Storage Instruction: Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol: NKX2-1
Gene ID: 7080
Uniprot ID: NKX21_HUMAN
Immunogen: A synthesized peptide derived from human NKX2-1
Tissue Specificity Thyroid and lung.
Post Translational Modifications Phosphorylated on serine residues by STK3/MST2.
Function Transcription factor that binds and activates the promoter of thyroid specific genes such as thyroglobulin, thyroperoxidase, and thyrotropin receptor. Crucial in the maintenance of the thyroid differentiation phenotype. May play a role in lung development and surfactant homeostasis. Forms a regulatory loop with GRHL2 that coordinates lung epithelial cell morphogenesis and differentiation. Activates the transcription of GNRHR and plays a role in enhancing the circadian oscillation of its gene expression. Represses the transcription of the circadian transcriptional repressor NR1D1.
Protein Name Homeobox Protein Nkx-2.1
Homeobox Protein Nk-2 Homolog A
Thyroid Nuclear Factor 1
Thyroid Transcription Factor 1
Ttf-1
Thyroid-Specific Enhancer-Binding Protein
T/Ebp
Database Links
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Homeobox Protein Nkx-2.1 antibody
Anti-Homeobox Protein Nk-2 Homolog A antibody
Anti-Thyroid Nuclear Factor 1 antibody
Anti-Thyroid Transcription Factor 1 antibody
Anti-Ttf-1 antibody
Anti-Thyroid-Specific Enhancer-Binding Protein antibody
Anti-T/Ebp antibody
Anti-NKX2-1 antibody
Anti-NKX2A antibody
Anti-TITF1 antibody
Anti-TTF1 antibody

Information sourced from Uniprot.org

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