Anti-Thyroglobulin antibody [2805] (STJ400205)

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STJ400205

£446.50 - £608.50
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Host: Mouse
Applications: ELISA
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Thyroglobulin is suitable for use in ELISA research applications.
Clonality: Monoclonal
Clone ID: 2805
Conjugation: Unconjugated
Isotype: IgG1
Formulation: 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative
Purification: Greater than 95% purity
Concentration: 5.0 mg/ml (+/-10 %)
Storage Instruction: 36 months from manufacturing at 2–8°C. Temperature analysis:-70 °C, 21 days N/D-20 °C, 21 days OK +4 °C, 21 days OK +30 °C, 21 OK +35 °C, 21 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer.
Association Rate Constant: 8.9 x 105 1/Ms
Determination Method: SPR analysis (ProteOn XPR36)
Immunoreactivity: 80–120 % compared to the reference sample in an FIA test
Gene Symbol: TG
Gene ID: 7038
Uniprot ID: THYG_HUMAN
Immunogen: Human thyroglobulin
Tissue Specificity Specifically expressed in the thyroid gland.
Post Translational Modifications Iodinated on tyrosine residues by TPO. There are 4 pairs of iodinated tyrosines used for coupling: acceptor Tyr-24 is coupled to donor Tyr-149 or Tyr-234, acceptor Tyr-2573 is coupled to donor Tyr-2540, acceptor Tyr-2766 in monomer 1 is coupled to donor Tyr-2766 in monomer 2 and acceptor Tyr-1310 in monomer 1 is coupled to donor Tyr-108 in monomer 2. Sulfated tyrosines are desulfated during iodination. Undergoes sequential proteolysis by cathepsins to release thyroxine (T4) and triiodothyronine (T3) hormones. In the thyroid follicle lumen, cross-linked TG (storage form) is solubilized by limited proteolysis mediated by cathepsins CTSB and/or CTSL. Partially cleaved TG is further processed by CTSK/cathepsin K and/or CTSL resulting in the release of T4. Following endocytosis, further processing occurs leading to the release of T3 and more T4 hormones.
Function Acts as a substrate for the production of iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). The synthesis of T3 and T4 involves iodination of selected tyrosine residues of TG/thyroglobulin followed by their oxidative coupling in the thyroid follicle lumen. Following TG re-internalization and lysosomal-mediated proteolysis, T3 and T4 are released from the polypeptide backbone leading to their secretion into the bloodstream. One dimer produces 7 thyroid hormone molecules.
Protein Name Thyroglobulin
Tg
Cellular Localisation Secreted
Secreted Into The Thyroid Follicle Lumen
Localizes To Colloid Globules
A Structure Formed In The Thyroid Follicle Lumen Consisting Of Cross-Linked Tg Arranged In Concentric Layers
Alternative Antibody Names Anti-Thyroglobulin antibody
Anti-Tg antibody
Anti-TG antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance