Anti-THUMPD2 antibody (299-349) (STJA0006425)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human THUM2 AA range: 299-349
General Information
| Short Description | Rabbit polyclonal anti-THUMP domain-containing protein 2 (299-349) for use in WB in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | THUMPD2 |
| Gene ID | 80745 |
| Uniprot ID | THUM2_HUMAN |
| Immunogen | Synthesized peptide derived from human THUM2 AA range: 299-349 |
| Immunogen Region | 299-349 |
| Specificity | This antibody detects endogenous levels of human THUM2 |
Additional Info
| Function | Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels. |
| Protein Name | U6 SnrnaGuanine-N(2-Methyltransferase Thumpd2Thump Domain-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-U6 Snrna antibodyAnti-Guanine-N(2-Methyltransferase Thumpd2 antibodyAnti-Thump Domain-Containing Protein 2 antibodyAnti-THUMPD2 antibodyAnti-C2orf8 antibody |
Information sourced from Uniprot.org