| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-THUMP domain-containing protein 2 (299-349) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:1000-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | THUMPD2 |
| Gene ID: | 80745 |
| Uniprot ID: | THUM2_HUMAN |
| Immunogen Region: | 299-349 |
| Specificity: | This antibody detects endogenous levels of human THUM2 |
| Immunogen: | Synthesized peptide derived from human THUM2 AA range: 299-349 |
| Function | Catalytic subunit of the THUMPD2-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotides, most probably at position 72 (m2G72), in the U6snRNA of the major spliceosome. This modification in the U6 snRNA affects the constitutive splicing efficiency of introns that have suboptimal splice sites and can impact final mRNA levels. |
| Protein Name | U6 SnrnaGuanine-N(2-Methyltransferase Thumpd2Thump Domain-Containing Protein 2 |
| Database Links | |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-U6 Snrna antibodyAnti-Guanine-N(2-Methyltransferase Thumpd2 antibodyAnti-Thump Domain-Containing Protein 2 antibodyAnti-THUMPD2 antibodyAnti-C2orf8 antibody |
Information sourced from Uniprot.org
