| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | THOP1 |
| Gene ID: | 7064 |
| Uniprot ID: | THOP1_HUMAN |
| Immunogen Region: | 1-260 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human THOP1 (NP_003240.1). |
| Immunogen Sequence: | MKPPAACAGDMADAASPCSV VNDLRWDLSAQQIEERTREL IEQTKRVYDQVGTQEFEDVS YESTLKALADVEVTYTVQRN ILDFPQHVSPSKDIRTASTE ADKKLSEFDVEMSMREDVYQ RIVWLQEKVQKDSLRPEAAR YLERLIKLGRRNGLHLPRET QENIKRIKKKLSLLCIDFNK NLNEDTTFLPFTLQELGGLP EDFLNSLEKMEDGKLKVTLK YPHYFPLLKKCHVPETRRK |
| Function | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1. |
| Protein Name | Thimet OligopeptidaseEndopeptidase 24.15Mp78 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thimet Oligopeptidase antibodyAnti-Endopeptidase 24.15 antibodyAnti-Mp78 antibodyAnti-THOP1 antibody |
Information sourced from Uniprot.org