| Host: | Mouse |
| Applications: | WB/IHC-P |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal anti-Thimet Oligopeptidase for use in WB and IHC-P in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Monoclonal |
| Clone ID : | 2D3 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Liquid in PBS containing 50% glycerol, 1% BSA and 0.02% sodium azide, pH 7.3. |
| Purification: | Affinity Purified |
| Concentration: | 0.67 mg/mL |
| Dilution Range: | WB 1:500-1:1000IHC 1:50-1:100 |
| Storage Instruction: | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
| Gene Symbol: | THOP1 |
| Gene ID: | 7064 |
| Uniprot ID: | THOP1_HUMAN |
| Immunogen: | Full length human recombinant protein of human THOP1 produced in 293T cell. |
| Function | Involved in the metabolism of neuropeptides under 20 amino acid residues long. Involved in cytoplasmic peptide degradation. Able to degrade the amyloid-beta precursor protein and generate amyloidogenic fragments. Also acts as a regulator of cannabinoid signaling pathway by mediating degradation of hemopressin, an antagonist peptide of the cannabinoid receptor CNR1. |
| Protein Name | Thimet OligopeptidaseEndopeptidase 24.15Mp78 |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Thimet Oligopeptidase antibodyAnti-Endopeptidase 24.15 antibodyAnti-Mp78 antibodyAnti-THOP1 antibody |
Information sourced from Uniprot.org
