| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Probable tRNAHis guanylyltransferase for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | THG1L |
| Gene ID: | 54974 |
| Uniprot ID: | THG1_HUMAN |
| Specificity: | This antibody detects endogenous levels of THG1L at Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from human THG1L |
| Function | Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. |
| Protein Name | Probable Trna(His GuanylyltransferaseInduced In High Glucose-1Ihg-1Interphase Cytoplasmic Foci Protein 45Trna-Histidine Guanylyltransferase |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmMitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Probable Trna(His Guanylyltransferase antibodyAnti-Induced In High Glucose-1 antibodyAnti-Ihg-1 antibodyAnti-Interphase Cytoplasmic Foci Protein 45 antibodyAnti-Trna-Histidine Guanylyltransferase antibodyAnti-THG1L antibodyAnti-ICF45 antibody |
Information sourced from Uniprot.org
