| Tissue Specificity | Expressed in many tissues. |
| Function | Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress. |
| Protein Name | Probable Trna(His GuanylyltransferaseInduced In High Glucose-1Ihg-1Interphase Cytoplasmic Foci Protein 45Trna-Histidine Guanylyltransferase |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | CytoplasmMitochondrion Outer Membrane |
| Alternative Antibody Names | Anti-Probable Trna(His Guanylyltransferase antibodyAnti-Induced In High Glucose-1 antibodyAnti-Ihg-1 antibodyAnti-Interphase Cytoplasmic Foci Protein 45 antibodyAnti-Trna-Histidine Guanylyltransferase antibodyAnti-THG1L antibodyAnti-ICF45 antibody |
Information sourced from Uniprot.org
