Anti-THAP1 antibody (150-210) (STJ503245)

SKU:
STJ503245-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-THAP1 (150-210) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.5-1.5 µg/µl
Dilution Range: WB: 1:500
ELISA: 1:10, 000
IP: 1:200
IHC: 1:50-1:150
ICC: 1:50-1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: THAP1
Gene ID: 55145
Uniprot ID: THAP1_HUMAN
Immunogen Region: 150-210
Immunogen: Synthetic peptide taken within amino acid region 150-210 on human THAP domain-containing protein 1.
Tissue Specificity Highly expressed in heart, skeletal muscle, kidney and liver. Weaker expression in brain and placenta.
Function DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-ATNTNNGTGGCAAGT-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes, including RRM1. Component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of RRM1. May also have pro-apoptotic activity by potentiating both serum-withdrawal and TNF-induced apoptosis.
Protein Name Thap Domain-Containing Protein 1
Cellular Localisation Nucleus
Nucleoplasm
Pml Body
Alternative Antibody Names Anti-Thap Domain-Containing Protein 1 antibody
Anti-THAP1 antibody

Information sourced from Uniprot.org

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