| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TGS1 |
| Gene ID: | 96764 |
| Uniprot ID: | TGS1_HUMAN |
| Immunogen Region: | 714-853 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 714-853 of human TGS1 (NP_079107.6). |
| Immunogen Sequence: | RVIAIDIDPVKIALARNNAE VYGIADKIEFICGDFLLLAS FLKADVVFLSPPWGGPDYAT AETFDIRTMMSPDGFEIFRL SKKITNNIVYFLPRNADIDQ VASLAGPGGQVEIEQNFLNN KLKTITAYFGDLIRRPASET |
| Tissue Specificity | Ubiquitously expressed. High expression in heart, skeletal muscle, kidney, liver and placenta. |
| Function | Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. |
| Protein Name | Trimethylguanosine SynthaseCll-Associated Antigen Kw-2Cap-Specific Guanine-N(2 MethyltransferaseHepatocellular Carcinoma-Associated Antigen 137Nuclear Receptor Coactivator 6-Interacting ProteinPrip-Interacting Protein With Methyltransferase MotifPimtPipmt |
| Database Links | Reactome: R-HSA-1368082Reactome: R-HSA-1368108Reactome: R-HSA-191859Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-2426168Reactome: R-HSA-381340Reactome: R-HSA-400206Reactome: R-HSA-400253Reactome: R-HSA-9707564Reactome: R-HSA-9707616 |
| Cellular Localisation | CytoplasmNucleusCajal BodyNucleolusA 90 Kda Isoform Is Found In The Nucleus While A 55 Kda Isoform Is Found In The Cytoplasm And Colocalizes With The Tubulin Network |
| Alternative Antibody Names | Anti-Trimethylguanosine Synthase antibodyAnti-Cll-Associated Antigen Kw-2 antibodyAnti-Cap-Specific Guanine-N(2 Methyltransferase antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 137 antibodyAnti-Nuclear Receptor Coactivator 6-Interacting Protein antibodyAnti-Prip-Interacting Protein With Methyltransferase Motif antibodyAnti-Pimt antibodyAnti-Pipmt antibodyAnti-TGS1 antibodyAnti-HCA137 antibodyAnti-NCOA6IP antibodyAnti-PIMT antibody |
Information sourced from Uniprot.org
