| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TGFBR3 |
| Gene ID: |
7049 |
| Uniprot ID: |
TGBR3_HUMAN |
| Immunogen Region: |
140-340 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 140-340 of human TGFBR3 (NP_003234.2). |
| Immunogen Sequence: |
ANFSLTAETEERNFPHGNEH LLNWARKEYGAVTSFTELKI ARNIYIKVGEDQVFPPKCNI GKNFLSLNYLAEYLQPKAAE GCVMSSQPQNEEVHIIELIT PNSNPYSAFQVDITIDIRPS QEDLEVVKNLILILKCKKSV NWVIKSFDVKGSLKIIAPNS IGFGKESERSMTMTKSIRDD IPSTQGNLVKWALDNGYSPI T |
| Post Translational Modifications | Extensively modified by glycosaminoglycan groups (GAG). Phosphorylated in the cytoplasmic domain by the type II receptor TGFBR2 at THR-840 to mediate recruitment of ARRB2 and subsequent internalization of TGFBR2 and TGFBR3. |
| Function | Cell surface receptor that regulates diverse cellular processes including cell proliferation, differentiation, migration, and apoptosis. Initiates BMP, inhibin, and TGF-beta signaling pathways by interacting with different ligands including TGFB1, BMP2, BMP5, BMP7 or GDF5. Alternatively, acts as a cell surface coreceptor for BMP ligands, serving to enhance ligand binding by differentially regulating BMPR1A/ALK3 and BMPR1B/ALK6 receptor trafficking. Promotes epithelial cell adhesion, focal adhesion formation and integrin signaling during epithelial cell spreading on fibronectin. By interacting with the scaffolding protein beta-arrestin2/ARRB2, regulates migration or actin cytoskeleton and promotes the activation of CDC42 as well as the inhibition of NF-kappa-B. In gonadotrope cells, acts as an inhibin A coreceptor and regulates follicle-stimulating hormone (FSH) levels and female fertility. Plays a role in the inhibition of directed and random cell migration in epithelial cells by altering the actin cytoskeletal organization. Participates in epithelial-mesenchymal transformation (EMT) upon binding to BMP2 or TGFB2, by activating the PAR6/SMURF1/RHOA pathway. (Microbial infection) May act as a receptor for human cytomegalovirus in different cell types by interacting with HCMV trimer composed of GO, GH and GL. |
| Protein Name | Transforming Growth Factor Beta Receptor Type 3Tgf-Beta Receptor Type 3Tgfr-3BetaglycanTransforming Growth Factor Beta Receptor IiiTgf-Beta Receptor Type Iii |
| Database Links | Reactome: R-HSA-1502540Reactome: R-HSA-190370Reactome: R-HSA-190373Reactome: R-HSA-201451Reactome: R-HSA-2173789Reactome: R-HSA-9839383Reactome: R-HSA-9839389Reactome: R-HSA-9839394Reactome: R-HSA-9839397Reactome: R-HSA-9839406 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSecretedExtracellular SpaceExtracellular MatrixExists Both As A Membrane-Bound Form And As Soluble Form In Serum And In The Extracellular Matrix |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Receptor Type 3 antibodyAnti-Tgf-Beta Receptor Type 3 antibodyAnti-Tgfr-3 antibodyAnti-Betaglycan antibodyAnti-Transforming Growth Factor Beta Receptor Iii antibodyAnti-Tgf-Beta Receptor Type Iii antibodyAnti-TGFBR3 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
