| Tissue Specificity | Highly expressed in the corneal epithelium. Expressed in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas. |
| Post Translational Modifications | Gamma-carboxylation is controversial. Gamma-carboxyglutamated.gamma-carboxyglutamate residues are formed by vitamin K dependent carboxylation.these residues may be required for binding to calcium. According to a more recent report, does not contain vitamin K-dependent gamma-carboxyglutamate residues. The EMI domain contains 2 expected intradomain disulfide bridges (Cys-49-Cys85 and Cys-84-Cys-97) and one unusual interdomain disulfide bridge to the second FAS1 domain (Cys-74-Cys-339). This arrangement violates the predicted disulfide bridge pattern of an EMI domain. |
| Function | Plays a role in cell adhesion. May play a role in cell-collagen interactions. |
| Protein Name | Transforming Growth Factor-Beta-Induced Protein Ig-H3Beta Ig-H3Kerato-EpithelinRgd-Containing Collagen-Associated ProteinRgd-Cap |
| Database Links | Reactome: R-HSA-977225 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixMay Be Associated Both With Microfibrils And With The Cell Surface |
| Alternative Antibody Names | Anti-Transforming Growth Factor-Beta-Induced Protein Ig-H3 antibodyAnti-Beta Ig-H3 antibodyAnti-Kerato-Epithelin antibodyAnti-Rgd-Containing Collagen-Associated Protein antibodyAnti-Rgd-Cap antibodyAnti-TGFBI antibodyAnti-BIGH3 antibody |
Information sourced from Uniprot.org
