| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TFPI |
| Gene ID: | 7035 |
| Uniprot ID: | TFPI1_HUMAN |
| Immunogen Region: | 29-224 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 29-224 of human TFPI (NP_001027452.1). |
| Immunogen Sequence: | DSEEDEEHTIITDTELPPLK LMHSFCAFKADDGPCKAIMK RFFFNIFTRQCEEFIYGGCE GNQNRFESLEECKKMCTRDN ANRIIKTTLQQEKPDFCFLE EDPGICRGYITRYFYNNQTK QCERFKYGGCLGNMNNFETL EECKNICEDGPNGFQVDNYG TQLNAVNNSLTPQSTKVPSL FVTKEGTNDGWKNAAH |
| Tissue Specificity | Mostly in endothelial cells. |
| Post Translational Modifications | O-glycosylated. |
| Function | Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. |
| Protein Name | Tissue Factor Pathway InhibitorTfpiExtrinsic Pathway InhibitorEpiLipoprotein-Associated Coagulation InhibitorLaci |
| Database Links | Reactome: R-HSA-140834 |
| Cellular Localisation | Isoform Alpha: SecretedIsoform Beta: Microsome MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Tissue Factor Pathway Inhibitor antibodyAnti-Tfpi antibodyAnti-Extrinsic Pathway Inhibitor antibodyAnti-Epi antibodyAnti-Lipoprotein-Associated Coagulation Inhibitor antibodyAnti-Laci antibodyAnti-TFPI antibodyAnti-LACI antibodyAnti-TFPI1 antibody |
Information sourced from Uniprot.org