Anti-TFDP1 antibody (311-410) [S5MR] (STJ11102295)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal DP1 (311-410) antibody for use in WB, IHC-P and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TFDP1 |
| Gene ID | 7027 |
| Uniprot ID | TFDP1_HUMAN |
| Immunogen Region | 311-410 |
| Immunogen Sequence | SGSCSAEDLKMARSLVPKAL EPYVTEMAQGTVGGVFITTA GSTSNGTRFSASDLTNGADG MLATSSNGSQYSGSRVETPV SYVGEDDEEDDDFNENDEDD |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 311-410 of human DP1/TFDP1 (Q14186). |
Additional Info
| Tissue Specificity | Highest levels in muscle. Also expressed in brain, placenta, liver and kidney. Lower levels in lung and pancreas. Not detected in heart. |
| Post Translational Modifications | Phosphorylation by E2F1-bound cyclin A-CDK2, in the S phase, inhibits E2F-mediated DNA binding and transactivation. Ubiquitinated by the BCR(KBTBD5) complex, leading to its subsequent degradation. |
| Function | Can stimulate E2F-dependent transcription. Binds DNA cooperatively with E2F family members through the E2 recognition site, 5'-TTTCCGCGC-3', found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The E2F1:DP complex appears to mediate both cell proliferation and apoptosis. Blocks adipocyte differentiation by repressing CEBPA binding to its target gene promoters. |
| Protein Name | Transcription Factor Dp-1Drtf1-Polypeptide 1Drtf1E2f Dimerization Partner 1 |
| Database Links | Reactome: R-HSA-111448Reactome: R-HSA-113501Reactome: R-HSA-1362277Reactome: R-HSA-1362300Reactome: R-HSA-139915Reactome: R-HSA-1538133Reactome: R-HSA-1912408Reactome: R-HSA-2173796Reactome: R-HSA-2559580Reactome: R-HSA-2559585Reactome: R-HSA-6804114Reactome: R-HSA-69202Reactome: R-HSA-69205Reactome: R-HSA-69231Reactome: R-HSA-69656Reactome: R-HSA-8953750Reactome: R-HSA-9616222Reactome: R-HSA-9661069 |
| Cellular Localisation | NucleusCytoplasmShuttles Between The Cytoplasm And Nucleus And Translocates Into The Nuclear Compartment Upon Heterodimerization With E2f1 |
| Alternative Antibody Names | Anti-Transcription Factor Dp-1 antibodyAnti-Drtf1-Polypeptide 1 antibodyAnti-Drtf1 antibodyAnti-E2f Dimerization Partner 1 antibodyAnti-TFDP1 antibodyAnti-DP1 antibody |
Information sourced from Uniprot.org