Anti-TERF2IP antibody (203-252 aa) (STJ95370)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human RAP1 at the amino acid range 203-252
General Information
| Short Description | Rabbit polyclonal anti-Telomeric repeat-binding factor 2-interacting protein 1 (203-252 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TERF2IP |
| Gene ID | 54386 |
| Uniprot ID | TE2IP_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human RAP1 at the amino acid range 203-252 |
| Immunogen Region | 203-252 aa |
| Specificity | RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein. |
Additional Info
| Function | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. |
| Protein Name | Telomeric Repeat-Binding Factor 2-Interacting Protein 1Terf2-Interacting Telomeric Protein 1Trf2-Interacting Telomeric Protein 1Dopamine Receptor-Interacting Protein 5Repressor/Activator Protein 1 HomologRap1 HomologHrap1 |
| Database Links | Reactome: R-HSA-110328Reactome: R-HSA-110329Reactome: R-HSA-110330Reactome: R-HSA-110331Reactome: R-HSA-1221632Reactome: R-HSA-171306Reactome: R-HSA-171319Reactome: R-HSA-174411Reactome: R-HSA-174414Reactome: R-HSA-174417Reactome: R-HSA-174430Reactome: R-HSA-174437Reactome: R-HSA-2559586Reactome: R-HSA-9670095 |
| Cellular Localisation | NucleusCytoplasmChromosomeTelomereAssociates With ChromosomesBoth At Telomeres And In Extratelomeric SitesAlso Exists As A Cytoplasmic FormWhere It Associates With The Ikk Complex |
| Alternative Antibody Names | Anti-Telomeric Repeat-Binding Factor 2-Interacting Protein 1 antibodyAnti-Terf2-Interacting Telomeric Protein 1 antibodyAnti-Trf2-Interacting Telomeric Protein 1 antibodyAnti-Dopamine Receptor-Interacting Protein 5 antibodyAnti-Repressor/Activator Protein 1 Homolog antibodyAnti-Rap1 Homolog antibodyAnti-Hrap1 antibodyAnti-TERF2IP antibodyAnti-DRIP5 antibodyAnti-RAP1 antibodyAnti-PP8000 antibody |
Information sourced from Uniprot.org