| Host: | Rabbit |
| Applications: | WB/IHC |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Telomeric repeat-binding factor 2-interacting protein 1 (203-252 aa) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 IHC-P 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TERF2IP |
| Gene ID: | 54386 |
| Uniprot ID: | TE2IP_HUMAN |
| Immunogen Region: | 203-252 aa |
| Specificity: | RAP1 Polyclonal Antibody detects endogenous levels of RAP1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human RAP1 at the amino acid range 203-252 |
| Function | Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. |
| Protein Name | Telomeric Repeat-Binding Factor 2-Interacting Protein 1 Terf2-Interacting Telomeric Protein 1 Trf2-Interacting Telomeric Protein 1 Dopamine Receptor-Interacting Protein 5 Repressor/Activator Protein 1 Homolog Rap1 Homolog Hrap1 |
| Database Links | Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110330 Reactome: R-HSA-110331 Reactome: R-HSA-1221632 Reactome: R-HSA-171306 Reactome: R-HSA-171319 Reactome: R-HSA-174411 Reactome: R-HSA-174414 Reactome: R-HSA-174417 Reactome: R-HSA-174430 Reactome: R-HSA-174437 Reactome: R-HSA-2559586 Reactome: R-HSA-9670095 |
| Cellular Localisation | Nucleus Cytoplasm Chromosome Telomere Associates With Chromosomes Both At Telomeres And In Extratelomeric Sites Also Exists As A Cytoplasmic Form Where It Associates With The Ikk Complex |
| Alternative Antibody Names | Anti-Telomeric Repeat-Binding Factor 2-Interacting Protein 1 antibody Anti-Terf2-Interacting Telomeric Protein 1 antibody Anti-Trf2-Interacting Telomeric Protein 1 antibody Anti-Dopamine Receptor-Interacting Protein 5 antibody Anti-Repressor/Activator Protein 1 Homolog antibody Anti-Rap1 Homolog antibody Anti-Hrap1 antibody Anti-TERF2IP antibody Anti-DRIP5 antibody Anti-RAP1 antibody Anti-PP8000 antibody |
Information sourced from Uniprot.org