• STJ70589 Immunofluorescence analysis of paraformaldehyde fixed HeLa cells, permeabilized with 0. 15% Triton. Primary incubation 1hr (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml) , showing plasma membrane and cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10ug/ml) followed by Alexa Fluor 488 secondary antibody (2ug/ml).

Anti-TEM8/Anthrax Toxin Receptor 1 antibody (C-Term) (STJ70589)

SKU:
STJ70589-100

£312.50
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Host: Goat
Applications: Pep-ELISA/IF
Reactivity: Human/Rat/Dog/Cow
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-TEM8/Anthrax Toxin Receptor 1 (C-Term) is suitable for use in ELISA and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: Peptide ELISA: antibody detection limit dilution 1:64000.
WB: Preliminary testing showed a band at approx 65-70kDa in lysate of cell lines A431 and U2OS after 1-2µg/ml antibody staining (calculated MW of 62.8kDa according to NP_115584.1). This ba
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ANTXR1
Gene ID: 84168
Uniprot ID: ANTR1_HUMAN
Immunogen Region: C-Term
Accession Number: NP_115584.1
Specificity: This antibody is expected to recognise variant 1 (NP_115584) only.
Immunogen Sequence: RAPPPSRPPPRPSV
Function Plays a role in cell attachment and migration. Interacts with extracellular matrix proteins and with the actin cytoskeleton. Mediates adhesion of cells to type 1 collagen and gelatin, reorganization of the actin cytoskeleton and promotes cell spreading. Plays a role in the angiogenic response of cultured umbilical vein endothelial cells. (Microbial infection) Acts as a receptor for protective antigen (PA) of B.anthracis.
Protein Name Anthrax Toxin Receptor 1
Tumor Endothelial Marker 8
Database Links Reactome: R-HSA-5210891
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Lamellipodium Membrane
Filopodium Membrane
At The Membrane Of Lamellipodia And At The Tip Of Actin-Enriched Filopodia
Colocalizes With Actin At The Base Of Lamellipodia
Alternative Antibody Names Anti-Anthrax Toxin Receptor 1 antibody
Anti-Tumor Endothelial Marker 8 antibody
Anti-ANTXR1 antibody
Anti-ATR antibody
Anti-TEM8 antibody

Information sourced from Uniprot.org

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