| Host: | Goat |
| Applications: | Pep-ELISA/IHC |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-TEB4/MARCH-VI (886-898) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:16000. WB: Preliminary experiments in human kidney, thymus and ovary lysates gave no specific signal but low background (at antibody concentration up to 1µg/ml). IHC: Paraffin embedded Human |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | MARCHF6 |
| Gene ID: | 10299 |
| Uniprot ID: | MARH6_HUMAN |
| Immunogen Region: | 886-898 |
| Accession Number: | NP_005876.2 |
| Immunogen Sequence: | QRLVNYERKSGKQ |
| Post Translational Modifications | Auto-ubiquitinated, which results in proteasomal degradation. |
| Function | E3 ubiquitin-protein ligase that promotes 'Lys-48'-linked ubiquitination of target proteins, leading to their proteasomal degradation. Promotes ubiquitination of DIO2, leading to its degradation. Promotes ubiquitination of SQLE, leading to its degradation. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May cooperate with UBE2G1. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf6 Doa10 Homolog Membrane-Associated Ring Finger Protein 6 Membrane-Associated Ring-Ch Protein Vi March-Vi Protein Teb-4 Ring Finger Protein 176 Ring-Type E3 Ubiquitin Transferase Marchf6 |
| Database Links | Reactome: R-HSA-901032 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf6 antibody Anti-Doa10 Homolog antibody Anti-Membrane-Associated Ring Finger Protein 6 antibody Anti-Membrane-Associated Ring-Ch Protein Vi antibody Anti-March-Vi antibody Anti-Protein Teb-4 antibody Anti-Ring Finger Protein 176 antibody Anti-Ring-Type E3 Ubiquitin Transferase Marchf6 antibody Anti-MARCHF6 antibody Anti-KIAA0597 antibody Anti-MARCH6 antibody Anti-RNF176 antibody Anti-TEB4 antibody |
Information sourced from Uniprot.org