Anti-TEAD4 antibody (140-240) [S5216RM] (STJ11105216)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal Transcriptional Enhancer Factor Tef-3 (140-240) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S5216RM |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | TEAD4 |
| Gene ID | 7004 |
| Uniprot ID | TEAD4_HUMAN |
| Immunogen Region | 140-240 |
| Immunogen Sequence | SATAFHSSMALARGPGRPAV SGFWQGALPGQAGTSHDVKP FSQQTYAVQPPLPLPGFESP AGPAPSPSAPPAPPWQGRSV ASSKLWMLEFSAFLEQQQDP D |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 140-240 of human TEAD4 (Q15561). |
Additional Info
| Tissue Specificity | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and non-cooperatively to the Sph and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription. Binds to the M-CAT motif. |
| Protein Name | Transcriptional Enhancer Factor Tef-3Tea Domain Family Member 4Tead-4Transcription Factor 13-Like 1Transcription Factor Rtef-1 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671Reactome: R-HSA-9796292Reactome: R-HSA-9819196 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-3 antibodyAnti-Tea Domain Family Member 4 antibodyAnti-Tead-4 antibodyAnti-Transcription Factor 13-Like 1 antibodyAnti-Transcription Factor Rtef-1 antibodyAnti-TEAD4 antibodyAnti-RTEF1 antibodyAnti-TCF13L1 antibodyAnti-TEF3 antibody |
Information sourced from Uniprot.org