| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-TEAD1/2/3/4 (174-263) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S8MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TEAD1 |
| Gene ID: |
7003 |
| Uniprot ID: |
TEAD1_HUMAN |
| Immunogen Region: |
174-263 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 174-263 of human TEAD4 (NP_003204.2) |
| Immunogen Sequence: |
SHDVKPFSQQTYAVQPPLPL PGFESPAGPAPSPSAPPAPP WQGRSVASSKLWMLEFSAFL EQQQDPDTYNKHLFVHIGQS SPSYSDPYLE |
| Tissue Specificity | Preferentially expressed in skeletal muscle. Lower levels in pancreas, placenta, and heart. |
| Function | Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds specifically and cooperatively to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3') and activates transcription in vivo in a cell-specific manner. The activation function appears to be mediated by a limiting cell-specific transcriptional intermediary factor (TIF). Involved in cardiac development. Binds to the M-CAT motif. |
| Protein Name | Transcriptional Enhancer Factor Tef-1Ntef-1Protein Gt-IicTea Domain Family Member 1Tead-1Transcription Factor 13Tcf-13 |
| Database Links | Reactome: R-HSA-2032785Reactome: R-HSA-8951671Reactome: R-HSA-9619665 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Enhancer Factor Tef-1 antibodyAnti-Ntef-1 antibodyAnti-Protein Gt-Iic antibodyAnti-Tea Domain Family Member 1 antibodyAnti-Tead-1 antibodyAnti-Transcription Factor 13 antibodyAnti-Tcf-13 antibodyAnti-TEAD1 antibodyAnti-TCF13 antibodyAnti-TEF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
