| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-TDRKH (36-355) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TDRKH |
| Gene ID: |
11022 |
| Uniprot ID: |
TDRKH_HUMAN |
| Immunogen Region: |
36-355 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 36-355 of human TDRKH (NP_001077432.1). |
| Immunogen Sequence: |
RYRESREERLTFVGEDDIEI EMRVPQEAVKLIIGRQGANI KQLRKQTGARIDVDTEDVGD ERVLLISGFPVQVCKAKAAI HQILTENTPVSEQLSVPQRS VGRIIGRGGETIRSICKASG AKITCDKESEGTLLLSRLIK ISGTQKEVAAAKHLILEKVS EDEELRKRIAHSAETRVPRK QPISVRREDMTEPGGAGEPA LWKNTSSSMEPTAPLVTPPP KGGGDMAVVVSKEGSWEKP |
| Post Translational Modifications | Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30. |
| Function | Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules. |
| Protein Name | Tudor And Kh Domain-Containing ProteinTudor Domain-Containing Protein 2 |
| Database Links | Reactome: R-HSA-5601884 |
| Cellular Localisation | CytoplasmMitochondrionProbable Component Of The Meiotic NuageAlso Named P GranuleA Germ-Cell-Specific Organelle Required To Repress Transposon Activity During MeiosisColocalizes With Pi- And Pip-BodiesA Subset Of The Nuage Which Contains Secondary PirnasAssociated With Mitochondria In The Germline |
| Alternative Antibody Names | Anti-Tudor And Kh Domain-Containing Protein antibodyAnti-Tudor Domain-Containing Protein 2 antibodyAnti-TDRKH antibodyAnti-TDRD2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
