| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-TDP1 (Internal) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
WB-1-3µg/mlELISA-antibody detection limit dilution 1:8000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
TDP1 |
| Gene ID: |
55775 |
| Uniprot ID: |
TYDP1_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_060789.2 |
| Specificity: |
Reported variants represent identical protein: NP_001008744.1, NP_060789.2 |
| Immunogen Sequence: |
PNDGTAQRTENHG |
| Post Translational Modifications | Phosphorylated on serine and/or threonine residues, but not on tyrosine residues. |
| Function | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 3'-phosphodiester bond, giving rise to DNA with a free 3' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase I active site tyrosine residue. Hydrolyzes 3'-phosphoglycolates on protruding 3' ends on DNA double-strand breaks due to DNA damage by radiation and free radicals. Acts on blunt-ended double-strand DNA breaks and on single-stranded DNA. Has low 3'exonuclease activity and can remove a single nucleoside from the 3'end of DNA and RNA molecules with 3'hydroxyl groups. Has no exonuclease activity towards DNA or RNA with a 3'phosphate. |
| Protein Name | Tyrosyl-Dna Phosphodiesterase 1Tyr-Dna Phosphodiesterase 1 |
| Database Links | Reactome: R-HSA-5693571 |
| Cellular Localisation | NucleusCytoplasm |
| Alternative Antibody Names | Anti-Tyrosyl-Dna Phosphodiesterase 1 antibodyAnti-Tyr-Dna Phosphodiesterase 1 antibodyAnti-TDP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
