| Post Translational Modifications | Ubiquitinated. Ubiquitination by the BCR(KCTD17) E3 ubiquitin ligase complex results in proteasomal degradation, and induces ciliogenesis. |
| Function | Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. Inhibits cell growth in bladder and prostate cancer cells by a down-regulation of HSPB1 by inhibiting its phosphorylation. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis. |
| Protein Name | Trichoplein Keratin Filament-Binding ProteinProtein TchpMitochondrial Protein With Oncostatic ActivityMitostatinTumor Suppressor Protein |
| Cellular Localisation | CytoplasmCytoskeletonCell MembraneMitochondrionCell JunctionDesmosome |
| Alternative Antibody Names | Anti-Trichoplein Keratin Filament-Binding Protein antibodyAnti-Protein Tchp antibodyAnti-Mitochondrial Protein With Oncostatic Activity antibodyAnti-Mitostatin antibodyAnti-Tumor Suppressor Protein antibodyAnti-TCHP antibody |
Information sourced from Uniprot.org
