| Tissue Specificity | Predominantly expressed in T-cells. Also detected in proliferating intestinal epithelial cells and in the basal epithelial cells of mammary gland epithelium. |
| Function | Transcriptional activator involved in T-cell lymphocyte differentiation. Necessary for the survival of CD4(+) CD8(+) immature thymocytes. Isoforms lacking the N-terminal CTNNB1 binding domain cannot fulfill this role. Binds to the T-lymphocyte-specific enhancer element (5'-WWCAAAG-3') found in the promoter of the CD3E gene. Represses expression of the T-cell receptor gamma gene in alpha-beta T-cell lineages. Required for the development of natural killer receptor-positive lymphoid tissue inducer T-cells. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7 and CTNNB1. May also act as feedback transcriptional repressor of CTNNB1 and TCF7L2 target genes. |
| Protein Name | Transcription Factor 7Tcf-7T-Cell-Specific Transcription Factor 1T-Cell Factor 1Tcf-1 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-8951430Reactome: R-HSA-9754189Reactome: R-HSA-9796292Reactome: R-HSA-9825892 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor 7 antibodyAnti-Tcf-7 antibodyAnti-T-Cell-Specific Transcription Factor 1 antibodyAnti-T-Cell Factor 1 antibodyAnti-Tcf-1 antibodyAnti-TCF7 antibodyAnti-TCF1 antibody |
Information sourced from Uniprot.org
