| Tissue Specificity | Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom. |
| Post Translational Modifications | In vitro, phosphorylated by TNIK. Phosphorylated at Thr-201 and/or Thr-212 by NLK. Phosphorylation by NLK at these sites inhibits DNA-binding by TCF7L2/TCF4, thereby preventing transcriptional activation of target genes of the canonical Wnt/beta-catenin signaling pathway. Polysumoylated. Sumoylation is enhanced by PIAS family members and desumoylation is enhanced by SENP2. Sumoylation/desumoylation regulates TCF7L2/TCF4 transcription activity in the Wnt/beta-catenin signaling pathway without altering interaction with CTNNB1 nor binding to DNA. |
| Function | Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as a repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. |
| Protein Name | Transcription Factor 7-Like 2Hmg Box Transcription Factor 4T-Cell-Specific Transcription Factor 4T-Cell Factor 4Tcf-4Htcf-4 |
| Database Links | Reactome: R-HSA-201722Reactome: R-HSA-3769402Reactome: R-HSA-381771Reactome: R-HSA-4086398Reactome: R-HSA-4411364Reactome: R-HSA-4641265Reactome: R-HSA-5339700Reactome: R-HSA-8853884Reactome: R-HSA-8951430Reactome: R-HSA-9823730Reactome: R-HSA-9825892 |
| Cellular Localisation | NucleusPml BodyDiffuse PatternColocalizes With Sumo1 And Pias4 In A Subset Of Pml (Promyelocytic Leukemia) Nuclear Bodies |
| Alternative Antibody Names | Anti-Transcription Factor 7-Like 2 antibodyAnti-Hmg Box Transcription Factor 4 antibodyAnti-T-Cell-Specific Transcription Factor 4 antibodyAnti-T-Cell Factor 4 antibodyAnti-Tcf-4 antibodyAnti-Htcf-4 antibodyAnti-TCF7L2 antibodyAnti-TCF4 antibody |
Information sourced from Uniprot.org
