| Host: |
Rabbit |
| Applications: |
IHC/IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Transcription factor E2-alpha (321-370 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IHC 1:100-1:300ELISA 1:5000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
TCF3 |
| Gene ID: |
6929 |
| Uniprot ID: |
TFE2_HUMAN |
| Immunogen Region: |
321-370 aa |
| Specificity: |
E2A Polyclonal Antibody detects endogenous levels of E2A protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human E2A at the amino acid range 321-370 |
| Function | Transcriptional regulator involved in the initiation of neuronal differentiation and mesenchymal to epithelial transition. Heterodimers between TCF3 and tissue-specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Together with TCF15, required for the mesenchymal to epithelial transition. Dimers bind DNA on E-box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. Isoform E47: Facilitates ATOH7 binding to DNA at the consensus sequence 5'-CAGGTG-3', and positively regulates transcriptional activity. |
| Protein Name | Transcription Factor E2-AlphaClass B Basic Helix-Loop-Helix Protein 21Bhlhb21Immunoglobulin Enhancer-Binding Factor E12/E47Immunoglobulin Transcription Factor 1Kappa-E2-Binding FactorTranscription Factor 3Tcf-3Transcription Factor Itf-1 |
| Database Links | Reactome: R-HSA-525793Reactome: R-HSA-8939236 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor E2-Alpha antibodyAnti-Class B Basic Helix-Loop-Helix Protein 21 antibodyAnti-Bhlhb21 antibodyAnti-Immunoglobulin Enhancer-Binding Factor E12/E47 antibodyAnti-Immunoglobulin Transcription Factor 1 antibodyAnti-Kappa-E2-Binding Factor antibodyAnti-Transcription Factor 3 antibodyAnti-Tcf-3 antibodyAnti-Transcription Factor Itf-1 antibodyAnti-TCF3 antibodyAnti-BHLHB21 antibodyAnti-E2A antibodyAnti-ITF1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
