| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TBX6 |
| Gene ID: | 6911 |
| Uniprot ID: | TBX6_HUMAN |
| Immunogen Region: | 1-436 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human TBX6 (NP_004599.2). |
| Immunogen Sequence: | MYHPRELYPSLGAGYRLGPA QPGADSSFPPALAEGYRYPE LDTPKLDCFLSGMEAAPRTL AAHPPLPLLPPAMGTEPAPS APEALHSLPGVSLSLENREL WKEFSSVGTEMIITKAGRRM FPACRVSVTGLDPEARYLFL LDVIPVDGARYRWQGRRWEP SGKAEPRLPDRVYIHPDSPA TGAHWMRQPVSFHRVKLTNS TLDPHGHLILHSMHKYQPRI HLVRAAQLCSQHWGGMASF |
| Tissue Specificity | Expressed in fetal tail bud, posterior spinal tissue, intervertebral disk and testis. Also expressed in adult testis, kidney, lung, muscle and thymus. |
| Function | T-box transcription factor that plays an essential role in the determination of the fate of axial stem cells: neural vs mesodermal. Acts in part by down-regulating, a specific enhancer (N1) of SOX2, to inhibit neural development. Seems to play also an essential role in left/right axis determination and acts through effects on Notch signaling around the node as well as through an effect on the morphology and motility of the nodal cilia. |
| Protein Name | T-Box Transcription Factor Tbx6T-Box Protein 6 |
| Database Links | Reactome: R-HSA-9793380Reactome: R-HSA-9824272Reactome: R-HSA-9832991 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-T-Box Transcription Factor Tbx6 antibodyAnti-T-Box Protein 6 antibodyAnti-TBX6 antibody |
Information sourced from Uniprot.org