| Host: | Rabbit |
| Applications: | WB/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-TBC1 domain family member 3 and TBC1 domain family member 3B and TBC1 domain family member 3C (481-530 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000ELISA 1:20000IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | TBC1D3TBC1D3C414060/729873101060321/414060/729873TBC3A_HUMANTBC3C_HUMANTBC3B_HUMAN |
| Immunogen Region: | 481-530 aa |
| Specificity: | TBC1D3A/B/C Polyclonal Antibody detects endogenous levels of TBC1D3A/B/C protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human TBC1D3 at the amino acid range 481-530 |
| Post Translational Modifications | Ubiquitinated by a CUL7-based E3 ligase, which leads to proteasomal degradation. Palmitoylation is required for membrane localization and protects TBC1D3 from ubiquitination. |
| Function | Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11. |
| Protein Name | Tbc1 Domain Family Member 3Prostate Cancer Gene 17 ProteinProtein Tre17-AlphaRab Gtpase-Activating Protein Prc17 |
| Database Links | Reactome: R-HSA-8854214 |
| Cellular Localisation | Cell MembraneLipid-AnchorAssociated With Lipid Rafts |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 3 antibodyAnti-Prostate Cancer Gene 17 Protein antibodyAnti-Protein Tre17-Alpha antibodyAnti-Rab Gtpase-Activating Protein Prc17 antibodyAnti-TBC1D3 antibodyAnti-PRC17 antibodyAnti-TBC1D3A antibody |
Information sourced from Uniprot.org