| Function | Acts as a GTPase-activating protein for Rab family protein(s). Essential for the establishment of male fertility, and is required for both the production of normal sperm number and sperm function. Plays an important role in the formation of intact mitochondria, outer dense fibers and axoneme within the sperm tail. Essential for sperm mitochondrial sheath formation and for the interactions of ARMC12 with VDAC2 and VDAC3. May be involved in acrosome formation and cytoskeletal reorganization during spermiogenesis, possibly by regulating RAB3A activity. |
| Protein Name | Tbc1 Domain Family Member 21Male Germ Cell Rab Gtpase-Activating Protein |
| Cellular Localisation | Cytoplasmic VesicleSecretory VesicleAcrosomeCytoplasmCytoskeletonLocated At The Edge Of The Acrosomal RegionNeck And Annulus During SpermiogenesisColocalizes With Rab3a At The Acrosome-Acroplaxome And Neck Regions Of SpermatidsColocalizes With Actb At The Neck Region In Elongated Spermatids |
| Alternative Antibody Names | Anti-Tbc1 Domain Family Member 21 antibodyAnti-Male Germ Cell Rab Gtpase-Activating Protein antibodyAnti-TBC1D21 antibodyAnti-MGCRABGAP antibody |
Information sourced from Uniprot.org
